医学技术专硕导师

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王一存博士,副教授,硕士研究生导师

邮箱:wangyicun@jlu.edu.cn

属性1 邮箱:wangyicun@jlu.edu.cn 属性2
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研究方向

噬菌体纳米医学

肿瘤致病机制

教育经历

2010/09–2014/06, 东北师范大学,细胞生物学, 博士

2008/09–2010/06, 东北师范大学,细胞生物学, 硕士

2004/09–2008/06 ,东北师范大学,生物技术, 学士

工作经历

2021/012–至今,吉林大学第二医院,研究中心,副教授

2016/5-2017/12, 阿拉巴马大学伯明翰校区,肿瘤中心,访问学者

2015/09–2016/05 ,匹兹堡大学,神经生物学,访问学者

2015/09–2021/12, 吉林大学第二医院,研究中心,讲师

教学项目

1.吉林大学励新优秀青年教师培养计划,主持

参编论著

1. Yicun Wang(王一存) , Li Wang. Vaccination with Phage-Displayed Antigenic Epitope .Methods Mol Biol. 2017:1625:225-235(论著)

科研项目(主持)

1.国家自然科学面上基金项目:三展示噬菌体-纳米系统应用于肺癌及其脑转移肿瘤精准诊疗的研究探索 2023.1-2026.12

2.国家自然科学青年基金项目:三展示噬菌体-纳米系统应用于白色念珠菌感染富集性检测和靶向治疗的研究 2019.1-2022.12

3.吉林省科技厅科创专员项目:2025.1-2026.12

4.吉林省科技厅科技创新创业卓越人才(团队)项目:吉林省噬菌体纳米预防诊疗系统的研究创新团队 2024.01-2026.12

5.吉林省科技厅重点研发:工程化噬菌体生物纳米材料应用于新冠病毒感染疫苗以及药物载体研发的探索 2023.01-2026.12

6.吉林省科技厅省联合基金白求恩医学专项:载药噬菌体复合纳米材料的制备及应用于前列腺癌靶向治疗的研究。2020.01-2022.12

7.吉林省科技厅青年人才项目:噬菌体磁性复合纳米材料的构建及其应用于白色念珠菌感染靶向治疗的研究2019.01-2020.12

8.吉林省财政厅:基于Hsp90和Sap2的噬菌体纳米材料应用于白色念珠菌诊治的研究 2020.01-2022.12

9.吉林省教育厅:靶向可载药噬菌体生物纳米材料应用于系统性白色念珠菌感染治疗的研究 2020.01-2021.12

10.吉林大学白求恩计划项目:噬菌体纳米材料应用于HPV阳性宫颈癌靶向精准治疗的研究 2022.7.1-2024.6.3

11.吉大二院自然科学基金培育项目:基于Hsp90和Sap2的噬菌体纳米材料应用于白色念珠菌诊治的研究 2019.1.1-2021.12.31

科研论文(第一责作者)

1.Zhou X, Wang Y, Bao M, Chu Y, Liu R, Chen Q, Lin Y.Advanced detection of cervical cancer biomarkers using engineered filamentous phage nanofibers.Appl Microbiol Biotechnol. 2024 Feb 19;108(1):221.

2.Wu Y, Fu H, Hao J, Yang Z, Qiao X, Li Y, Zhao R, Lin T, Wang Y, Wang M. Tumor-derived exosomal PD-L1: a new perspective in PD-1/PD-L1 therapy for lung cancer.Front Immunol. 2024 Mar 18;15:1342728.

3.Xu S, Zhang G, Zhang J, Liu W, Wang Y, Fu X.Advances in Brain Tumor Therapy Based on the Magnetic Nanoparticles.Int J Nanomedicine. 2023 Dec 20;18:7803-7823.

4.Yicun Wang Guangxin Zhang, Lili Zhong, Meng Wang, Ranji Cui, Filamentous bacteriophages, natural nanoparticles, for viral vaccine strategies. Nanoscale. 2022;14(16):5942-5959

5.Guangxin Zhang, Meng Wang, Tie Lin, Wei Liu, Yicun Wang. Phage nanoparticle as a carrier for controlling fungal infection. Appl Microbiol Biotechnol. 2022.106(9-10):3397-3403.

6.Yuer Zhang, Yunjiao Wu, Xinyi Qiao, Tie Lin, Yicun Wang, Meng Wang. Biomaterial-based strategy for bone tumor therapy and bone defect regeneration: An innovative application option.Front. Mater, 2022.9: 990931(通讯)

7.Yicun Wang, Jiyao Sheng, Jin Chai, Cuilin Zhu, Xin Li, Wei Yang, Ranji Cui,Tongtong Ge. Filamentous Bacteriophage-A Powerful Carrier for Glioma Therapy. Front Immunol. 2021, 10:12:729336.

8.Wang YC . Liu W, Li BJ, Chen DQ, Wang LZ, Liu XG, Cui RJ, Liu RH. MicroRNA-1205, encoded on chromosome 8q24, targets EGLN3 to induce cell growth and contributes to risk of castration-resistant prostate cancer Oncogene . 2019 Jun;38(24):4820-4834. IF:9.8

9. Wang YC, Shi HX, Dong S, Li Y, Wang M ,Huai YY, Zhang XT , Chen X , Mao CB , Gao X.Nontoxic engineered virus nanofibers as an efficient agent for the prevention and detection of fungal infection. Nano Res. 2018: 11(4) : 2248-2255.

10.Xin Li , Yang Lin , Gang Yao, Yicun Wang. The Influence of Vaccine on Febrile Seizure. Curr Neuropharmacol. 2018;16(1):59-65.

11.Song Gao, Yicun Wang, Zhi Li , Zhiying Zhao , Raymond X Wang , Rong Wu , Zhengwei Yuan , Ranji Cui , Kai Jiao , Lizhong Wang, Ling Ouyang , Runhua Liu. MicroRNA-155, induced by FOXP3 through transcriptional repression of BRCA1, is associated with tumor initiation in human breast cancer. Oncotarget.2017;8(25):41451-41464. (共一)

12.Peter A Neumann , Yicun Wang, Yijin Yan , Yao Wang , Masago Ishikawa , Ranji Cui , Yanhua H Huang , Susan R Sesack , Oliver M Schlüter , Yan Dong.Cocaine-Induced Synaptic Alterations in Thalamus to Nucleus Accumbens Projection.Neuropsychopharmacology. 2016 ;41(9):2399-410.

13.Wang YC, Ju ZG, Cao BR, Gao X ,Zhu Y, Qiu PH , Xu H, Pan PT, Bao HZ, Wang L,Mao CB.Ultrasensitive rapid detection of human serum antibody biomarkers by biomarker- capturing viral nanofibers.ACS Nano. 2015;9(4):4475-4483.

14.Pan PT, Wang YC, Zhu Y, Gao X , Ju ZG , Qiu PH, Wang L, Mao CB。 Nontoxic virus nanofibers improve the detection sensitivity for the anti-p53 antibody, a biomarker in cancer patients. Nano Res 2015 Nov;8(11):3562-3570.

15.Wang Y, Su Q, Dong S, Shi H, Gao X, Wang L. Hybrid phage displaying SLAQVKYTSASSI induces protection against Candida albicans challenge in BALB/c mice. Hum Vaccin Immunother. 2014;10(4):1057-63.

16.Yicun Wang, Shuohui Gao, Jiayin Lv, Yang Lin, Li Zhou, Liying Han. Phage Display Technology and its Applications in Cancer Immunotherapy. Anticancer Agents Med Chem2019;19(2):229-235.

授权专利

一种用于检测白色念珠菌的噬菌体复合纳米线 2016.04.06- 2034.09.09 中国 CN201410456311.9 (专利)

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