张美双

医学博士，讲师

E-mail：zhangmeishuang@jlu.edu.cn

研究方向

代谢性疾病康复

教育经历

2016.09-2019.12 吉林大学基础医学院，药理学专业，医学博士

2013.09-2016.06 长春中医药大学，中药学专业，医学硕士

2009.09-2013.06 吉林农业大学，中药学专业，理学学士

工作经历

2021年5月至今，吉林大学护理学院，讲师

教学项目

1. 基于“OBE理念+CBL教学法”提升康复药理学教学效果的研究，吉林省高教科研项目，负责

科研项目

1. 乳酸调控PPARγ蛋白乳酰化修饰在运动改善肥胖中的分子机制研究，国家自然科学基金青年基金项目，负责人

2. 运动通过抑制HIF-1α/miR-27a调控脂肪组织能量代谢改善肥胖，吉林省科技厅青年成长科技计划项目，负责人

3. miR-27a通过抑制CREB与PPARγ调控脂肪组织能量代谢进而引发肥胖的作用机制研究，吉林省教育厅科学技术研究项目，负责人

4. 运动产生乳酸调控PPARγ蛋白乳酰化修饰改善肥胖的分子机制研究，吉林大学白求恩计划项目，负责人

科研论文

1. Meishuang Zhang^#, Hongwei Du^#, Yueqi Guan, Jingyue Liu, Sushan Wang, Haoran Li, Wenyou Zhang, Hao Han, Ming Zhang*, Li Chen*. Study on the Effect of PDA-PLGA Scaffold Loaded With Islet Cells for Skeletal Muscle Transplantation in the Treatment of Diabetes[J]. Front Bioeng Biotechnol, 2022, 10:927348.

2. Meishuang Zhang, Yining Zhang, Dong Xiao, Jing Zhang, Xinxin Wang, Fengying Guan, Ming Zhang*, Li Chen*. Highly bioavailable berberine formulation ameliorates diabetic nephropathy through the inhibition of glomerular mesangial matrix expansion and the activation of autophagy[J]. Eur J Pharmacol, 2020, 873:172955.

3. Meishuang Zhang, Shidong Sheng, Wenyou Zhang, Jing Zhang, Zhanqiang Zhang, Ming Zhang*, Grant M Hatch, Li Chen*. MiR27a Promotes the Development of Macrophage-like Characteristics in 3T3-L1 Preadipocytes[J]. Int J Biol Sci, 2018, 14(11):1599-1609.

4. Tianyu Zhao, Tangsheng Zhong, Meishuang Zhang, Yang Xu, Ming Zhang*, Li Chen*. Alzheimer's Disease: Causal Effect between Obesity and APOE Gene Polymorphisms[J]. Int J Mol Sci, 2023, 24(17):13531.

5. Jia Xu, Yining Zhang, Zhiyi Yu, Yueqi Guan, Yuqian Lv, Meishuang Zhang, Ming Zhang, Li Chen, Xiaoyan Lv*, Fengying Guan*. Berberine mitigates hepatic insulin resistance by enhancing mitochondrial architecture via the SIRT1/Opa1 signalling pathway[J]. Acta Biochim Biophys Sin, 2022, 54(10):1464-1475.

6. Lufang Zheng, Cong Wang, Yiming Qiu, Xin Li, Xueyan Zhang, Meishuang Zhang, Tianjiao Ma, Guichen Li*, Li Chen*. Effectiveness of interventions in older adults with cognitive frailty: a systematic review and meta-analysis of randomised controlled trials[J]. Age Ageing, 2022, 51(12):1-10.

7. Peiqi Liu, Li Chen, Tangsheng Zhong, Meishuang Zhang, Tianjiao Ma, Huimin Tian*. Impact of calorie intake and refeeding syndrome on the length of hospital stay of patients with malnutrition: a systematic review and meta-analysis[J]. Clin Nutr, 2022, 41(9):2003-2012.

8. Xiaoyan Lv, Yali Zhao, Xuehan Yang, Hao Han, Yue Ge, Meishuang Zhang, Hansi Zhang*, Ming Zhang*, Li Chen. Berberine Potentiates Insulin Secretion and Prevents β-cell Dysfunction Through the miR-204/SIRT1 Signaling Pathway[J]. Front Pharmacol, 2021, 12:720866.

9. Junnan Li^#, Hongwei Du^#, Meishuang Zhang, Zhi Zhang, Fei Teng, Yali Zhao, Wenyou Zhang, Yang Yu, Linjing Feng, Xinming Cui, Ming Zhang, Tzongshi Lu, Fengying Guan*, Li Chen*. Amorphous solid dispersion of Berberine mitigates apoptosis via iPLA2β/Cardiolipin/Opa1 pathway in db/db mice and in Palmitate-treated MIN6 β-cells[J]. Int J Biol Sci, 2019, 15(7):1533-1545.

社会兼职

中国药理学会，会员