王立生

医学博士，教授，博士研究生导师

邮箱：lishengwang@jlu.edu.cn

研究方向

1. 干细胞基因治疗与再生医学

2. 生物治疗与组织再生康复

主持或参加的科研项目

1. 国家重点研发计划：“iPSC-RPE治疗AMD和Stargardt病的多中心临床试验”,负责人

2. 北京市吴祖泽科技发展基金会:“间充质干细胞外泌体水凝胶伤口敷料的制备及性能研究”，负责人

3. 吉林省科学技术厅：“间充质干细胞基因治疗关键技术及治疗缺血性疾病制剂研发”，负责人

4. 横向项目：“PD-L1抗体靶向偶联NK细胞及技术研究”，负责人

5. 横向项目：“索拉菲尼纳米药物的制备”，负责人

科研论文

1. Zu W, Huang X, Xu T, Du L, Wang Y, Wang L^*, & Nie, W. (2023). Machine learning in predicting outcomes for stroke patients following rehabilitation treatment: A systematic review. PloS one, 18(6), e0287308.

2. Zhang L, Zhang X, Liu Y, Zhang W, Wu CT, Wang L^*. (2023). CD146+ Umbilical Cord Mesenchymal Stem Cells Exhibit High Immunomodulatory Activity and Therapeutic Efficacy in Septic Mice. Journal of inflammation research, 16, 579–594.

3. Chen M, Jiang J, Chen J, Wang M, Lu Y, Liu L, Zhao L, Wang L^*. (2023). The Clinical Safety and Efficacy of Targeted PD-L1 Therapy with Durvalumab in Solid Tumors. Current drug targets, 24(7), 584-598.

4. Du L, Du J, Yang M, Xu Q, Huang J, Tan W, Xu T, Wang L^*, Nie W, Zhao L. (2023). Development and external validation of a machine learning-based prediction model for the cancer-related fatigue diagnostic screening in adult cancer patients: a cross-sectional study in China. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 31(2), 106.

5. Nie W, Huang X, Zhao L, Wang T, Zhang D, Xu T, Du L, Li Y, Zhang W, Xiao F,  Wang L^*. (2023). Exosomal miR-17-92 derived from human mesenchymal stem cells promotes wound healing by enhancing angiogenesis and inhibiting endothelial cell ferroptosis. Tissue & cell, 83, 102124.

6. Huang X, Zan T, Tang J, Zhang D, Zu W, Wang T, Wang L^*, Nie W. (2022). Psychometric properties of the Chinese version of the attitude towards pressure ulcer prevention instrument: A cross-sectional survey. International wound journal, 19(8), 2019-2030.

7. Du L, Zhao L, Xu T, Wang Y, Zu W, Huang X, Nie W, Wang L^*. (2022). Blended learning vs traditional teaching: The potential of a novel teaching strategy in nursing education - a systematic review and meta-analysis. Nurse education in practice, 63, 103354.

8. Huang X, Wang T, Zu W, Xu T, Du L, Wang Y, Nie W, Wang L^*. (2022). A bibliometric analysis of global publications on graft-versus-host disease research. Medicine, 101(27), e29634.

9. Wang S, Yin H, Liu Z, Jia Y, Shang B, Meng Q, Yan M, Wang L^*, Chen L. (2021). How Exercise Protects Against Mild Cognitive Impairment in Nursing Home-Dwelling Older Adults: A Path Analysis. The Journal of nervous and mental disease, 209(9), 674-680.

10. Wang S, Yin H, Meng Q, Yan M, Wang L. ^* Chen L. (2021). Experiences of nursing home-dwelling older adults with mild cognitive impairment participating in a Chinese square dancing program: A qualitative study. Geriatric nursing (New York, N.Y.), 42(2), 405-411.

11. Li Y, Zhang L, Xu T, Zhao X, Jiang X, Xiao F, Sun H, Wang L^*. (2022). Aberrant ENPP2 expression promotes tumor progression in multiple myeloma. Leukemia & lymphoma, 63(4), 963-974.

12. Nie W, Xu P, Hao C, Chen Y, Yin Y, Wang L^*. (2020). Efficacy and safety of over-the-counter analgesics for primary dysmenorrhea: A network meta-analysis. Medicine, 99(19), e19881.

13. Wang S, Yin H, Meng X, Shang B, Meng Q, Zheng L, Wang L ^*, Chen L. (2020). Effects of Chinese square dancing on older adults with mild cognitive impairment. Geriatric nursing (New York, N.Y.), 41(3), 290-296.

14. Li Y, Gao Y, Liang B, Nie W, Zhao L, Wang L^*. (2020). Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling. Experimental and therapeutic medicine, 20(6), 262.

15. Nie W, Tang J, Zulkowski K, Wang L ^*, Zan T. (2020). Psychometric Properties of the Chinese Version of the Pieper-Zulkowski Pressure Ulcer Knowledge Test in Nursing Practice: A Cross-sectional Survey. Advances in skin & wound care, 33(5), 1-7.

16. Li Y, Xiao F, Zhang A, Zhang D, Nie W, Xu T, Han B, Seth P, Wang H, Yang Y,  Wang L^*. (2020). Oncolytic adenovirus targeting TGF-β enhances anti-tumor responses of mesothelin-targeted chimeric antigen receptor T cell therapy against breast cancer. Cellular immunology, 348, 104041.

17. Nie WB, Zhang D, Wang LS^*. (2020). Growth Factor Gene-Modified Mesenchymal Stem Cells in Tissue Regeneration. Drug design, development and therapy, 14, 1241-1256.

18. Wang S, Yin H, Wang X, Jia Y, Wang C, Wang L ^*, & Chen, L. (2019). Efficacy of different types of exercises on global cognition in adults with mild cognitive impairment: a network meta-analysis. Aging clinical and experimental research, 31(10), 1391-1400.

参编专著

1.《再生医学转化与应用》2017，人民卫生出版社，参编

2. 《再生医学研究与转化应用》2017，科学出版社，秘书组组长

获得专利

1. 发明专利：一种用于促进造血细胞增殖的组合物及其应用, 2022-06-28, 中国, CN201910763545.0

2. 发明专利：抑制ENPP2基因和/或蛋白表达的物质在制备治疗多发性骨髓瘤的药物中的应用, 2020-12-09, 中国, CN202011450542.0

社会兼职

中国医药生物技术协会再生医学专业委员会，秘书长

中国抗癌协会血液病转化医学专业委员会，副主任委员

中国毒理学会生物技术药物安全性评价专业委员会，副主任委员

中国研究型医院学会理论与实践创新分会，指导专家